Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) Peptide
ACCN2
适用: 小鼠
宿主: 合成
BP, WB
Quick Overview for Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) Peptide (ABIN972800)
抗原
ASIC1 (ACCN2)
(Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
宿主
小鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- MELKTEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF
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产品特性
- This is a synthetic peptide designed for use in combination with anti-Accn2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) peptide
ACCN2 宿主: 合成 BP, WB, IHC
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
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背景
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Accn2 is a cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+, Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.
Alias Symbols: AI843610, ASIC, ASIC1, ASIC1a, B530003N02Rik, BNaC2, Accn2
Protein Size: 526 -
分子量
- 60 kDa
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基因ID
- 11419
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NCBI登录号
- NM_009597, NP_033727
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UniProt
- Q6NXK8
抗原
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